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Related Experiment Videos

The murine cripto gene: expression during mesoderm induction and early heart morphogenesis

R Dono1, L Scalera, F Pacifico

  • 1International Institute of Genetics and Biophysics, CNR, Naples, Italy.

Development (Cambridge, England)
|August 1, 1993
PubMed
Summary

The murine cripto gene, similar to its human counterpart, is expressed in specific adult organs and early embryonic tissues. Its restricted expression pattern during embryogenesis suggests a role in mesoderm development.

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Area of Science:

  • Developmental Biology
  • Molecular Genetics
  • Gene Expression Analysis

Background:

  • The cripto gene encodes an epidermal growth factor-related protein.
  • Murine and human cripto genes share high similarity in the 'EGF-like' domain.
  • Murine cripto mRNA exhibits homology to human mRNA and contains B1 repeats.

Purpose of the Study:

  • To investigate the expression pattern of the murine cripto gene during embryogenesis.
  • To elucidate the potential role of the cripto gene in early developmental processes.

Main Methods:

  • In situ hybridization was employed to analyze cripto gene expression.
  • Expression analysis was conducted during murine embryogenesis from day 6.2 to day 10.5.

Main Results:

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  • Low-level expression of the mouse cripto gene was observed in adult spleen, heart, lung, and brain.
  • During embryogenesis, cripto transcripts were first detected in epiblastic cells at day 6.5.
  • Expression localized to the forming mesoderm during gastrulation and later to the truncus arteriosus of the developing heart.

Conclusions:

  • The murine cripto gene exhibits a highly restricted expression pattern during embryonic development.
  • This expression pattern suggests a crucial role for the cripto gene in epiblastic cell determination and mesoderm formation.