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d-amphetamine conditioned place preference in developing mice: relations with changes in activity and stereotypies
G Laviola1, G Dell'Omo, F Chiarotti
1Section of Behavioral Pathophysiology, Istituto Superiore di Sanità, Rome, Italy.
Behavioral Neuroscience
|June 1, 1994
Summary
d-amphetamine induced conditioned place preference (CPP) in mice, with females showing preference earlier than males. Stereotypies, potentially indicating negative effects, influenced the drug
Area of Science:
- Neuroscience
- Pharmacology
- Developmental Biology
Background:
- Amphetamine use can lead to conditioned place preference (CPP), indicating its rewarding effects.
- Developmental stages may influence drug responses, including behavioral and hedonic impacts.
Purpose of the Study:
- To investigate the age-dependent effects of d-amphetamine on conditioned place preference (CPP), hyperactivity, and stereotypies in developing mice.
- To compare the developmental trajectory of d-amphetamine CPP with that of cocaine CPP.
Main Methods:
- CD-1 mice at 2, 3, and 4 weeks of age were administered single doses of d-amphetamine (1-10 mg/kg).
- Behavioral responses including CPP (using visual and tactile cues), hyperactivity, and stereotypies were assessed.
Main Results:
- Female mice exhibited CPP from 2 weeks of age, while males showed it from 3 weeks.
- Hyperactivity was significantly greater in postweanling mice (3 and 4 weeks) compared to preweanling mice.
- Stereotypies occurred from the youngest age and peaked at 3 weeks, suggesting potential aversive effects.
Conclusions:
- The development of d-amphetamine CPP is age-dependent, with females showing earlier acquisition than males.
- Stereotypies, possibly linked to negative affective states, may modulate the rewarding effects of d-amphetamine.
- The delayed development of d-amphetamine CPP compared to cocaine CPP might be due to age-dependent negative effects of amphetamine not present with cocaine.