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Interactions between econazole, a broad-spectrum antimicrobic substance, and topically active glucocorticoids
Dermatologica
|January 1, 1976
Summary
Glucocorticoids can protect cell membranes from the antifungal econazole in yeasts but not in staphylococci. This study investigated the interaction between econazole nitrate and glucocorticoids in topical therapies.
Area of Science:
- Dermatology
- Pharmacology
- Microbiology
Background:
- Econazole is a broad-spectrum antimicrobial agent that disrupts cell membranes.
- Glucocorticoids possess surface activity that may protect cell membranes.
Purpose of the Study:
- To investigate the potential protective effect of glucocorticoids against econazole nitrate.
- To evaluate the interaction between econazole and glucocorticoids in topical therapy.
Main Methods:
- Warburg assays were used to assess the effects on yeasts and bacteria.
- Skin blanching reactions were evaluated to determine in vivo effects.
Main Results:
- Glucocorticoids demonstrated a protective effect against econazole nitrate in yeasts, but not in staphylococci.
- The skin blanching response to triamcinolone acetonide was unaffected by econazole nitrate.
Conclusions:
- Glucocorticoids may offer some protection against econazole's membrane-permeabilizing effects in certain microorganisms.
- The findings have implications for the combined use of antimicrobials and glucocorticoids in topical treatments.