Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The vasoactive peptidergic system

G Tamburino1, L S Malatino

  • 1Istituto di Clinica Medica Generale e Terapia Medica L. Condorelli, Università degli Studi di Catania.

Annali Italiani Di Medicina Interna : Organo Ufficiale Della Societa Italiana Di Medicina Interna
|April 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Endogenous ouabain and cardiomyopathy in dialysis patients.

Journal of internal medicine·2007
Same author

Circulating E-selectin as a risk marker in patients with end-stage renal disease.

Journal of internal medicine·2007
Same author

Fibrinogen, mortality and incident cardiovascular complications in end-stage renal failure.

Journal of internal medicine·2003
Same author

Fibrinogen, inflammation and concentric left ventricular hypertrophy in chronic renal failure.

European journal of clinical investigation·2003
Same author

Circulating natriuretic peptide concentrations in patients with end-stage renal disease: role of brain natriuretic peptide as a biomarker for ventricular remodeling.

Mayo Clinic proceedings·2001
Same author

Long-term CAPD patients are volume expanded and display more severe left ventricular hypertrophy than haemodialysis patients.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2001

A hypothetical peptidergic system influences local vasomotion and modulates circulation. This system, involving various peptide families, shows involvement in tissue ischemia, particularly in the heart and brain.

Area of Science:

  • Molecular biology
  • Physiology
  • Cardiovascular research

Background:

  • Emerging evidence suggests a hypothetical peptidergic system for local control of vasomotion.
  • This system appears to modulate established circulatory homeostasis systems like the adrenergic and renin-angiotensin systems.
  • The full physiology of this peptidergic system remains incompletely understood.

Purpose of the Study:

  • To explore the role of a hypothetical peptidergic system in local vasomotion control.
  • To investigate the involvement of this system in pathophysiological conditions such as tissue ischemia.
  • To synthesize current understanding of peptides regulating vascular function.

Main Methods:

  • Review of molecular biology studies.
  • Analysis of human and animal models of tissue ischemia (myocardium, brain).

Related Experiment Videos

  • Investigation of peptide families including endothelins, natriuretic peptides, peptides Y, calcitonin gene-related peptides, tachykinins, and tissue angiotensins.

    • Main Results:

    • Suggestive evidence supports the existence and function of a perivascular peptidergic system.
    • This system plays a role in the local control of vasomotion.
    • Involvement in pathophysiological conditions like myocardial and cerebral ischemia is indicated.

    Conclusions:

    • The peptidergic system is a significant, albeit not fully understood, regulator of local vascular tone.
    • Further research is needed to elucidate the complete physiological and pathophysiological roles of this system.
    • This system represents a potential target for understanding and treating circulatory disorders.