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Trends in primary cerebral lymphoma

J M Lutz1, M P Coleman

  • 1Thames Cancer Registry, Sutton, Surrey, UK.

British Journal of Cancer
|October 1, 1994
PubMed
Summary

Primary brain lymphoma incidence has rapidly increased in southeast England since 1985. This rise in non-Hodgkin lymphoma (NHL) cases is unexplained by diagnostic improvements or HIV, necessitating further investigation into potential causes.

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Area of Science:

  • Neurology
  • Oncology
  • Epidemiology

Background:

  • Primary non-Hodgkin lymphoma (NHL) of the brain is a rare malignancy, accounting for approximately 1% of all NHL cases.
  • An increasing incidence of primary cerebral NHL has been observed in south-east England, particularly since 1985.

Purpose of the Study:

  • To investigate the trend in primary brain lymphoma incidence in south-east England.
  • To explore potential explanations for the observed increase in cerebral lymphoma cases.

Main Methods:

  • Analysis of 17,322 NHL cases registered between 1973 and 1990.
  • Focus on the 210 cases of primary cerebral NHL within the study cohort.
  • Examination of diagnostic, coding, and registration practices.

Main Results:

  • A significant increase in primary cerebral NHL diagnoses was noted, with 86% occurring between 1985 and 1990.
  • The rise in cerebral lymphoma is not fully explained by diagnostic advancements or changes in cancer registration.
  • The increase affects all age groups and both sexes, and is not solely attributable to HIV-related immunosuppression or general NHL trends.

Conclusions:

  • The observed rapid increase in primary brain lymphoma incidence in south-east England warrants further investigation.
  • Existing explanations, including diagnostic improvements and HIV-related immunosuppression, do not adequately account for this trend.
  • Further research is needed to identify the underlying causes of this concerning rise in cerebral lymphoma.

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