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Cardiac transplantation at UCLA

A Ardehali1, H Laks, D C Drinkwater

  • 1Department of Surgery, UCLA School of Medicine.

Clinical Transplants
|January 1, 1993
PubMed
Summary
This summary is machine-generated.

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Selecting oversized donor cardiac allografts for patients with pulmonary hypertension may be unnecessary.

Transplantation proceedings·2014

Heart transplant numbers are rising, but donor organ scarcity remains a challenge. Recent UCLA data shows improved outcomes in heart transplant patients, even with sicker recipients.

Area of Science:

  • Cardiology
  • Transplantation Medicine
  • Immunology

Background:

  • Heart transplantation is increasingly common due to broader indications.
  • Donor organ scarcity limits the number of procedures performed.
  • UCLA has performed 320 adult heart transplants through 1992.

Purpose of the Study:

  • To analyze heart transplant outcomes at UCLA.
  • To identify factors influencing patient survival and post-transplant complications.
  • To evaluate trends in patient outcomes over time.

Main Methods:

  • Retrospective analysis of 320 adult heart transplant recipients at UCLA (through 1992).
  • Categorization of transplant indications: ischemic cardiomyopathy (54%), dilated cardiomyopathy (33%), and others (4%).

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  • Assessment of post-transplant outcomes including rejection episodes, infections, mortality, and survival rates.

    • Main Results:

    • 1-year, 3-year, and 5-year survival rates were 84.3%, 74.3%, and 67.5%, respectively.
    • Early mortality (30-day) was 5.7%.
    • Patients transplanted in 1991-1992 showed improved outcomes (shorter hospital stay, fewer infections/rejections) despite a higher proportion of critically ill patients (UNOS Status 1).

    Conclusions:

    • Heart transplantation outcomes are improving, with comparable survival for ischemic and dilated cardiomyopathy.
    • Survival rates are similar in older (≥60 years) and younger (<60 years) heart transplant recipients.
    • Recent advancements in care have led to better patient outcomes, even in critically ill patients.