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Related Experiment Videos

Fibrinogen and aging

K Hager1, M Felicetti, G Seefried

  • 1Chair of Internal Medicine-Gerontology, University of Erlangen-Nürnberg, Germany.

Aging (Milan, Italy)
|April 1, 1994
PubMed
Summary
This summary is machine-generated.

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Plasma fibrinogen levels increase with age, posing a significant risk for cardiovascular and cerebrovascular diseases. This age-dependent rise in fibrinogen is more pronounced than that of blood glucose or cholesterol.

Area of Science:

  • Cardiovascular Medicine
  • Hematology
  • Gerontology

Background:

  • Plasma fibrinogen is a recognized risk factor for cardiovascular and cerebrovascular diseases.
  • Understanding the age-dependency of fibrinogen is crucial for risk assessment.

Purpose of the Study:

  • To evaluate the age-dependency of plasma fibrinogen concentration.
  • To compare the age-related increase of fibrinogen with other blood components.

Main Methods:

  • Determined plasma fibrinogen and other blood components in 156 individuals aged 23-96 years.
  • Analyzed data from healthy participants and excluded those with pathological findings or risk factors.

Main Results:

  • Plasma fibrinogen increased by approximately 25 mg/dL per decade in healthy individuals.

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  • In individuals over 65 years, 81% had fibrinogen levels exceeding 320 mg/dL, a level associated with increased cardiovascular risk.
  • The age-dependent rise in fibrinogen was more significant than that of blood glucose or cholesterol.

    • Conclusions:

    • Plasma fibrinogen concentration exhibits a significant age-dependent increase.
    • Elevated fibrinogen levels in older adults may contribute to increased cardio- and cerebrovascular risk.
    • Interleukin-6 (IL-6) may mediate the age-related rise in fibrinogen through various physiological processes.