Related Experiment Video
Updated: Aug 19, 2026

Reaction Kinetics and Combustion Dynamics of I4O9 and Aluminum Mixtures
Published on: November 7, 2016
A historical note on the iodine-sulphuric acid reaction of amyloid
Abstract:
The historical development of the iodine-sulphuric acid reaction for amyloid is described. The reaction dates back to 1814 when Colin and Gaultier de Claubry, and independently Stromeyer, introduced the iodine reaction for starch. A variant of the acidified iodine reaction appears to have been used for printing paper by Gmelin in 1829, and in 1838 Schleiden used the iodine-sulphuric acid test on plants to demonstrate what he considered to be a transformation of the plant material into starch. Shortly afterwards Payen (1839) defined "cellulose", and the iodine-sulphuric acid reaction became a standard procedure used by botanists to demonstrate this plant component. In 1853 Virchow used Harting's (1847) procedure to demonstrate the reaction of Purkynĕ's corpora amylacea to this test, on the assumption that they might be cellulose derivatives, and applied it to what appeared to be similar corpuscles in a "waxy" spleen. The first histochemical reaction for amyloidosis had thus been introduced into pathology, and continued to exert from that time on an important influence on amyloid research, whose impact is felt to the present day.
More Related Videos
Related Concept Videos
Preparation and Reactions of Thiols
Acid Halides to Esters: Alcoholysis
Aryldiazonium Salts to Azo Dyes: Diazo Coupling
Amines to Sulfonamides: The Hinsberg Test
Generally, a primary amine reacts with the Hinsberg reagent to produce an N-substituted benzenesulfonamide. The electron-withdrawing sulfonyl...
Redox Titration: Iodimetry and Iodometry
Phase II Reactions: Sulfation and Conjugation with α-Amino Acids

