Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The relationship between cholesterol and stroke

D R Jacobs1

  • 1University of Minnesota, Minneapolis 55454.

Health Reports
|January 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Subgingival Microbiota and Longitudinal Glucose Change: The Oral Infections, Glucose Intolerance and Insulin Resistance Study (ORIGINS).

Journal of dental research·2019
Same author

White Matter Lesion Penumbra Shows Abnormalities on Structural and Physiologic MRIs in the Coronary Artery Risk Development in Young Adults Cohort.

AJNR. American journal of neuroradiology·2019
Same author

Association of plasma phospholipid polyunsaturated and trans fatty acids with body mass index: results from the Multi-Ethnic Study of Atherosclerosis.

International journal of obesity (2005)·2017
Same author

Persistent organic pollutants in adipose tissue should be considered in obesity research.

Obesity reviews : an official journal of the International Association for the Study of Obesity·2016
Same author

Oxidative stress, anti-oxidants and the cross-sectional and longitudinal association with depressive symptoms: results from the CARDIA study.

Translational psychiatry·2016
Same author

Higher pericardial adiposity is associated with prevalent diabetes: The Coronary Artery Risk Development in Young Adults study.

Nutrition, metabolism, and cardiovascular diseases : NMCD·2016
Same journal

Patient experiences with virtual health care in Canada: Modes of delivery and satisfaction with care.

Health reports·2026
Same journal

Canadian Active Living Environments 2.0: Development of an open-source pipeline for the replication and extension of the Canadian Active Living Environments measure.

Health reports·2026
Same journal

Enhancing the OncoSim-Breast model using Canadian breast density information.

Health reports·2026
Same journal

Geographic variation in female breast cancer incidence and mortality in Canada.

Health reports·2026
Same journal

Prevalence and correlates of self-reported fair or poor oral health in Canada.

Health reports·2026
Same journal

Validating the Warwick-Edinburgh Mental Well-being Scale for the positive mental health surveillance of adults in Canada.

Health reports·2026
See all related articles

Blood cholesterol influences stroke risk differently for hemorrhagic and nonhemorrhagic types. Lower cholesterol may increase hemorrhagic stroke risk, while high levels are linked to nonhemorrhagic stroke.

Area of Science:

  • Neurology
  • Cardiovascular Medicine
  • Epidemiology

Background:

  • General epidemiologic studies show weak links between total cholesterol and total stroke.
  • Some Japanese studies suggest lower cholesterol increases hemorrhagic stroke risk, but lack high-cholesterol data.

Purpose of the Study:

  • To investigate the differential relationship between blood cholesterol levels and hemorrhagic versus nonhemorrhagic stroke.
  • To explore the underlying pathology and cholesterol's influence beyond blood pressure.

Main Methods:

  • Analysis of epidemiologic data from Japanese studies, Honolulu Heart Study, and MRFIT Screening Study.
  • Pathologic examination of arterial lesions in relation to stroke type and cholesterol levels.
  • Comparison of cholesterol's influence on stroke versus coronary heart disease.

Related Experiment Videos

Main Results:

  • Hemorrhagic stroke risk associated with lower cholesterol levels; nonhemorrhagic stroke risk with highest cholesterol levels.
  • Pathologic differences noted: arteriolosclerosis (inverse cholesterol relation) in hemorrhagic stroke, atherosclerosis (positive cholesterol relation) in nonhemorrhagic stroke.
  • Blood cholesterol influences stroke independently of blood pressure, with opposing effects on stroke types.

Conclusions:

  • Blood cholesterol plays a distinct role in hemorrhagic and nonhemorrhagic stroke development.
  • Cholesterol's influence on atherosclerotic stroke is less pronounced than on coronary heart disease.