Modification of in vivo Ca(2+)-uptake by parenterally administered aluminum complexes

The parental administration of complexed aluminum induces a very significant increase of Ca(2+0-uptake by various tissues. The effects are more important with aluminum-ATP complex than with the simultaneous administration of aluminum lactate and sodium ATP. In the last case the increase in calcium uptake does not reach the many fold (up to 7 times) values observed with aluminum-ATP complex. In this aluminum-induced modification of cellular calcium homeostasis ATP appears to act as a mediator of the metal complex effects. These experimental results emphasize the importance of the role of ATP in the biological properties of low molecular weight metal complexes.