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Inhibition by lead of the calcium plateau current at mouse motor nerve endings
1Medical Institute of Environmental Hygiene, Heinrich-Heine-University Düsseldorf, Department of Neurotoxicology, Germany.
Neuroreport
|June 27, 1994
Abstract:
The inhibition by lead of motor terminal calcium plateau signals has been studied using extracellular, perineuronal electrodes applied to the M. triangularis sterni preparation of the mouse. The long-lasting calcium pateau signal induced by 3,4-DAP (250 mumol) and TEA (10 mmol) blockade of presynaptic potassium channels was irreversibly blocked by micromolar lead concentrations in a concentration-dependent manner. These results suggest that lead antagonizes neuronal calcium channels involved in transmitter release from motor nerve terminals.