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Neurotransmitter transporters

D Attwell1, P Mobbs

  • 1Department of Physiology, University College London, UK.

Current Opinion in Neurobiology
|June 1, 1994
PubMed
Summary

Recent advances have significantly improved our understanding of neurotransmitter transporters. This enhanced knowledge reveals their crucial roles in nervous system development and disease, and their potential as therapeutic drug targets.

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Area of Science:

  • Neuroscience
  • Molecular Biology
  • Pharmacology

Background:

  • Neurotransmitter transporters are crucial for regulating synaptic signaling.
  • Recent years have seen significant advancements in understanding these molecules.

Purpose of the Study:

  • To summarize recent progress in the field of neurotransmitter transporters.
  • To highlight the implications of these findings for neuroscience and drug development.

Main Methods:

  • Cloning of novel plasma membrane uptake carriers.
  • Biochemical and physiological characterization of transporter function.

Main Results:

  • Identification of new members in two families of neurotransmitter transporters.
  • Improved understanding of transporter stoichiometry, function, and modulation.
  • Emerging evidence for the role of transporters in nervous system development and disease.

Conclusions:

  • Neurotransmitter transporters are key players in neuronal function and development.
  • These transporters represent promising targets for novel therapeutic strategies.
  • Further research into neurotransmitter transporters will likely yield significant clinical benefits.

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