Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Late onset dysthyroid optic neuropathy

P I Chou¹, S E Feldon

¹Doheny Eye Institute, University of Southern California School of Medicine, Los Angeles.

Thyroid : Official Journal of the American Thyroid Association

|January 1, 1994

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Electrophilic PPARγ ligands inhibit corneal fibroblast to myofibroblast differentiation in vitro: a potentially novel therapy for corneal scarring.

Experimental eye research·2011

Same author

Anticancer Role of PPARgamma Agonists in Hematological Malignancies Found in the Vasculature, Marrow, and Eyes.

PPAR research·2010

Same author

Regulation of Lymphocyte Function by PPARgamma: Relevance to Thyroid Eye Disease-Related Inflammation.

PPAR research·2008

Same author

The relation of Graves' ophthalmopathy to circulating thyroid hormone status.

The British journal of ophthalmology·2003

Same author

Adrenergic supersensitivity of rabbit choroidal blood vessels after sympathetic denervation.

Current eye research·2002

Same author

The use of autologous fibrinogen concentrate in treating ocular hypotony after glaucoma filtration surgery.

Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics·2002

Rare cases of late-onset dysthyroid optic neuropathy occurred years after stable Graves' ophthalmopathy. Vision improved with corticosteroids or surgery, suggesting mechanical vascular factors in optic nerve decompensation.

Area of Science:

Ophthalmology
Endocrinology

Background:

Dysthyroid optic neuropathy (DON) is a rare complication of Graves' ophthalmopathy.
It typically occurs during active phases of thyroid eye disease.

Observation:

Three middle-aged patients presented with rare late-onset DON.
Optic neuropathy developed 7-12 years after their Graves' ophthalmopathy stabilized.
No signs of orbital inflammation reactivation were present.

Findings:

Vision loss in these cases responded to corticosteroid treatment or surgical decompression.
Patients had no concurrent diabetes, hypertension, or cardiovascular disease.
This presentation is atypical for standard DON.

Implications:

Related Experiment Videos

The findings suggest that mechanical vascular factors may cause optic nerve decompensation in stable Graves' ophthalmopathy.
This highlights the need to consider non-inflammatory mechanisms in late-onset DON.
Further research into vascular etiologies of DON is warranted.