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Related Experiment Videos

Anaphylaxis in isolated rabbit lungs

T S Hakim, C A Dawson, V L Moore

    Respiration; International Review of Thoracic Diseases
    |January 1, 1978
    PubMed
    Summary
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    Blood and plasma factors significantly contribute to allergic lung responses in sensitized rabbits. These factors mediate specific immunological reactions, increasing lung and airway resistance after antigen challenge.

    Area of Science:

    • Immunology
    • Respiratory Physiology

    Background:

    • Allergic lung diseases involve complex immune responses.
    • The role of blood components in mediating immediate hypersensitivity reactions in the lungs requires further elucidation.

    Purpose of the Study:

    • To investigate the contribution of blood and plasma factors to antigen-induced allergic lung responses in a rabbit model.
    • To determine if blood or plasma from sensitized animals can elicit an allergic response in normal lungs.

    Main Methods:

    • Isolated rabbit lungs from ovalbumin or bovine gamma-globulin sensitized animals were perfused with autologous blood.
    • Antigen challenge was administered via the perfusate.
    • Responses were measured by changes in perfusion resistance, airway resistance, and lung compliance.

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    Main Results:

    • Immunologically specific responses, including increased perfusion and airway resistance, were observed after antigen challenge.
    • Allergic responses were elicited even when normal lungs were perfused with blood/plasma from sensitized animals.
    • The magnitude of the response was greater when blood or plasma from sensitized animals was used.

    Conclusions:

    • Blood and/or plasma factors are major contributors to antigen-induced allergic lung responses.
    • These factors play a crucial role in mediating the immediate hypersensitivity reactions in the respiratory system.