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Chromosome 11q23 abnormalities in leukaemia
1Leukaemia Research Fund Centre, Institute of Cancer Research, London, United Kingdom.
Leukemia & Lymphoma
|June 1, 1994
Summary
Chromosomal breakpoints at 11q23 are linked to leukaemia development, often involving the HRX gene. Disruption of HRX through translocation contributes to leukaemic processes, including infant and secondary leukaemias.
Area of Science:
- Genetics
- Molecular Biology
- Oncology
Background:
- Chromosomal breakpoints at band 11q23 are recurrent in primary and secondary leukaemias.
- These breakpoints are clustered within a 15kb region of the HRX gene.
- The HRX gene product shows homology to Drosophila trithorax, suggesting a role in transcriptional regulation.
Purpose of the Study:
- To investigate the role of HRX gene disruption in leukaemogenesis.
- To identify and characterize partner genes involved in 11q23 translocations.
- To explore the potential function of homologous genes on chromosomes 9p22 and 19p13.
Main Methods:
- Analysis of chromosomal breakpoints in leukaemia patients.
- Gene cloning and characterization of translocation partners.
- Homology analysis of identified genes.
Main Results:
- Breakpoints in leukaemia are concentrated in the HRX gene.
- HRX disruption via translocation is implicated in infant and drug-induced secondary leukaemias.
- Reciprocal genes on chromosomes 4q21, 9p22, and 19p13 have been cloned and characterized.
- High homology between genes on 9p22 and 19p13 was observed.
Conclusions:
- HRX gene disruption is a key event in 11q23-associated leukaemias.
- Translocations involving 11q23 contribute to leukaemic transformation.
- Homologous genes on 9p22 and 19p13 may play significant roles in leukaemic phenotype generation.