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[Tuberculosis in patients after kidney transplantation]
D Rowińska1, M Durlik, L Gradowska
1Instytutu Transplantologii AM, Warszawie.
Pneumonologia I Alergologia Polska
|January 1, 1994
Summary
Tuberculosis (TB) is a frequent complication in renal allograft recipients (RAR), impacting patient and graft survival. Early diagnosis and treatment of TB in RAR can lead to successful outcomes and remission.
Area of Science:
- Nephrology
- Infectious Diseases
- Transplantation Immunology
Background:
- Tuberculosis (TB) is a significant health concern in Poland.
- Renal allograft recipients (RAR) are susceptible to opportunistic infections like TB.
- The impact of TB on RAR outcomes requires thorough investigation.
Purpose of the Study:
- To analyze the effect of tuberculosis (TB) on patient and graft survival in renal allograft recipients (RAR).
- To evaluate the clinical manifestations, diagnosis, and treatment of TB in this patient population.
Main Methods:
- Retrospective analysis of 1669 renal allograft recipients transplanted between 1981 and 1992.
- Identification of 33 patients who developed tuberculosis (TB) post-transplantation.
- Review of patient records for immunosuppressive regimens, TB treatment, and outcomes.
Main Results:
- Tuberculosis developed in 2% of RAR (33 patients), with both early and late onset post-transplant.
- Pulmonary TB was most common (30 patients), but extrapulmonary TB (15 patients) was also frequent.
- Successful TB treatment (median 7.8 months) achieved remission in 24 patients, but overall one-year patient survival was 75% and graft survival was 49%.
Conclusions:
- Tuberculosis is a frequent complication in RAR, necessitating early diagnosis and treatment for successful management.
- Extrapulmonary TB is a notable presentation in RAR.
- TB significantly deteriorates patient and graft survival rates in RAR, underscoring the importance of vigilant monitoring and prompt intervention.