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Related Experiment Videos

A genetic map of the mouse with 4,006 simple sequence length polymorphisms

W F Dietrich1, J C Miller, R G Steen

  • 1Whitehead Institute/MIT Center for Genome Research, Cambridge, Massachusetts 02142.

Nature Genetics
|June 1, 1994
PubMed
Summary

Researchers created a detailed genetic map of the mouse genome using 4,006 simple sequence length polymorphisms (SSLPs). This high-resolution map significantly advances mouse genetic research and disease studies.

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Area of Science:

  • Genomics
  • Mouse Genetics

Background:

  • Accurate genetic maps are crucial for understanding genome organization and function.
  • Previous mouse genetic maps had limitations in marker density and coverage.

Purpose of the Study:

  • To construct a high-density genetic map of the mouse genome.
  • To provide a valuable resource for positional cloning and comparative genomics in mice.

Main Methods:

  • Development and genotyping of 4,006 simple sequence length polymorphisms (SSLPs).
  • Integration of SSLP data to create a comprehensive genetic map.

Main Results:

  • A genetic map with an average marker spacing of 0.35 centiMorgans (cM) was generated.
  • Approximately 90% of the mouse genome is within 1.1 cM of a marker.

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  • Markers exhibited a 50% polymorphism rate in laboratory mouse crosses, with some underrepresentation on the X chromosome.

    • Conclusions:

    • The constructed map represents a significant advancement in mouse genome mapping.
    • This resource facilitates gene discovery and functional studies in mouse models.
    • Further development aims to reach a 6,000 SSLP marker density.