[What age limit should be established for sperm donors?]

The absolute frequency of offsprings with diseases due to new autosomal dominant mutations in sperm, is growing according to paternal age. But a careful review of literature upon this topic as well as the actual estimation of the increased number of affected offspring within the limited number of newborns issued from semen donors, lead to moderate the conservative conclusions of american authors favoring a severe limitation of the upper limit of age for semen donors.