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Related Experiment Videos

Growth hormone receptor and binding protein: distribution and function

A C Herington1

  • 1Centre for Child Growth and Hormone Research, Royal Children's Hospital, Melbourne, Australia.

The Journal of Pediatric Endocrinology
|July 1, 1993
PubMed
Summary

The growth hormone receptor (GHR) and growth hormone binding protein (GHBP) play key roles in growth hormone (GH) action. Emerging research suggests GHBP acts as an endocrine, autocrine/paracrine, and intracrine factor, expanding our understanding of GH signaling.

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Area of Science:

  • Endocrinology
  • Molecular Biology
  • Cellular Biology

Background:

  • The precise molecular mechanisms underlying growth hormone (GH) action are not fully understood.
  • The growth hormone receptor (GHR) and growth hormone binding protein (GHBP) are crucial components in GH signaling pathways.
  • Existing research has focused on structural aspects, generation, and localization of GHR and GHBP.

Purpose of the Study:

  • To elucidate the multifaceted roles of GHR and GHBP in GH action.
  • To explore the independent physiological regulation of GHR and GHBP.
  • To develop a comprehensive model for GH action incorporating novel functions of GHBP.

Main Methods:

  • Analysis of structural forms of GHR and GHBP.
  • Investigation of GHBP generation mechanisms.

Related Experiment Videos

  • Studies on cellular distribution and localization of GHR and GHBP.
  • Examination of independent physiological regulation of GHR and GHBP.

    • Main Results:

    • Characterization of distinct structural forms of GHR and GHBP.
    • Identification of specific mechanisms governing GHBP generation.
    • Detailed mapping of cellular distribution and localization patterns for GHR and GHBP.
    • Understanding the consequences of independent physiological regulation of GHR and GHBP.

    Conclusions:

    • A multi-functional model for GH action is emerging.
    • GHBP, beyond its association with the cell membrane GHR, functions significantly as an endocrine factor.
    • GHBP also exhibits important autocrine/paracrine and potentially intracrine roles in GH signaling.