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Related Experiment Videos

A multifaceted intervention for infants with failure to thrive. A prospective study

P H Casey1, K J Kelleher, R H Bradley

  • 1Department of Pediatrics, University of Arkansas for Medical Sciences, Arkansas Children's Hospital, Little Rock.

Archives of Pediatrics & Adolescent Medicine
|October 1, 1994
PubMed
Summary

This study found that a multifaceted intervention did not reduce failure to thrive (FTT) in preterm infants. However, higher compliance with the intervention was linked to improved 3-year IQ and behavior in children with FTT.

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Area of Science:

  • Pediatrics
  • Developmental Psychology
  • Public Health

Background:

  • Failure to thrive (FTT) is a significant concern in preterm infants with low birth weights.
  • Early interventions aim to improve developmental outcomes in this vulnerable population.

Purpose of the Study:

  • To evaluate a multifaceted intervention's impact on FTT incidence and 3-year developmental outcomes (intelligence, health, growth, behavior) in preterm infants.
  • To assess if the intervention improved outcomes for children who developed FTT.

Main Methods:

  • A 3-year prospective, randomized clinical trial involving 914 preterm infants with low birth weights across 8 US university hospitals.
  • Intervention included weekly/biweekly home visits for family support and curricula, plus a 5-day/week child development center program until age 3.

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  • Outcomes measured included FTT incidence, 3-year intelligence (IQ), health, growth, and behavior status.

    • Main Results:

    • The intervention did not significantly decrease the incidence of FTT (20% vs. 22% in control).
    • No overall differences in 3-year outcomes were observed between treatment and control groups for children with FTT.
    • However, treatment group assignment predicted higher 36-month IQ (P=.005) after controlling for other factors.
    • Higher compliance with the intervention correlated with better 3-year IQ and behavior scores in children with FTT.

    Conclusions:

    • The multifaceted intervention did not alter FTT incidence or overall 3-year outcomes in this cohort.
    • Significant positive effects on 3-year IQ were observed after controlling for covariates.
    • The beneficial impact on IQ was most pronounced in families with higher adherence to the intervention program.