Paraproteinaemic neuropathy

Neuropathies associated with myeloma and with primary (AL) amyloid have been recognized for many years but are rare. Those related to benign monoclonal gammopathies have only been identified relatively recently but are now accepted as an important cause of late onset neuropathy. The clinical features in many of them resemble those of chronic inflammatory demyelinating polyneuropathy (CIDP) but the relationship between these two conditions remains a matter for debate.