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Genotoxicity assessment of Rokanol B2 and Rokamid R1
E Janik-Spiechowicz1, B Barański, E Dziubałtowska
1Department of Carcinogenesis, Teratogenesis and Mutagenesis, Nofer Institute of Occupational Medicine, Lodz, Poland.
Abstract:
Two surface-active compounds, Rokanol B2 and Rokamid R1, were examined with three types of screening tests: 1. standard Ames test in vitro using S. typhimurium TA97a, TA98, TA100 and TA102 strains; 2. micronucleus test in vivo; 3. sister chromatid exchange (SCE) on bone marrow cells of Balb C mice. Negative results of the testing, in terms of the effects of activity of both the technical preparations on S. typhimurium cells and bone marrow of Balb C mice, were found for both tested chemicals.