A uniform labeling system for bone marrow and peripheral blood stem cells

Area of Science:

• Hematology
• Transfusion Medicine
• Laboratory Science

Background:

• Bone marrow (BM) and peripheral blood stem cell (PBSC) processing, including separation, purging, and cryopreservation, are routine clinical laboratory procedures.
• The American Association of Blood Banks (AABB) has provided standards for BM and PBSC processing since 1991, aligning them with blood component standards.
• Existing AABB guidelines lack a uniform labeling system for BM/PBSC preparations, creating potential identification risks.

Purpose of the Study:

• To present a novel labeling system for definitive identification of allogeneic BM and autologous BM/PBSC collections.
• To ensure accurate tracking of all components from collection to final disposition, preventing misidentification.
• To propose a universal labeling system for AABB-accredited transfusion services.

Main Methods:

• Development and implementation of a standardized labeling system for BM and PBSC products.
• Adaptation of a transfusion service computer system with specific BM/PBSC component names and codes.
• Utilizing existing AABB guidelines for blood component labeling as a foundation.

Main Results:

• The proposed system provides definitive identification for allogeneic BM and autologous BM/PBSC collections.
• The system effectively identifies all components derived from the original product throughout its lifecycle.
• The adapted computer system offers a validated mechanism for labeling, tracking, and final disposition.

Conclusions:

• The implemented labeling system significantly reduces the risk of component misidentification, especially with simultaneous collections.
• A universal labeling system for BM/PBSC preparations is feasible and beneficial for AABB-accredited transfusion services.
• Adoption of this system enhances patient safety and laboratory efficiency in stem cell processing.