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Rabbit gastric lipase in biocatalytic resolution of 2-hydroxyalkyldiphenylphosphines
H B Kagan1, M Tahar, J C Fiaud
1Laboratoire de Synthèse Asymétrique, URA CNRS 1497, Université Paris-Sud, Orsay, France.
Bioorganic & Medicinal Chemistry
|January 1, 1994
Abstract:
Kinetic resolution of 2-hydroxyalkyldiphenylphosphines 4 by acylation with isopropenyl acetate was carried out under rabbit gastric lipase (RGL) catalysis to give optically active 4 and the corresponding acetate, the enantioselectivity factors E ranging from 10 to 20. 1-(2-Naphthyl)ethanol and 2-[N-(ethoxycarbonyl)amino]1-butanol 7 were also resolved.