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Indolocarbazole protein kinase C inhibitors from rebeccamycin
S Fabre1, M Prudhomme, M Sancelme
1Université Blaise Pascal, Laboratoire de Chimie Organique Biologique, URA 485, Aubière, France.
Bioorganic & Medicinal Chemistry
|February 1, 1994
Abstract:
Structural modifications were carried out on rebeccamycin, an antitumour antibiotic, to obtain analogues. The inhibitory potencies of these analogues against protein kinase C are compared. The method described represents an alternative route to the staurosporine aglycone, a potent protein kinase C inhibitor.