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Urinary biochemistry in occupational exposure to glycol ethers
J Laitinen1, J Liesivuori, T Turunen
1Kuopio Regional Institute of Occupational Health, Section of Occupational Hygiene and Toxicology, Finland.
Abstract:
Glycol ethers and glycol ether acetates are dehydrogenated to alkoxyacetic acid congeners which may serve as biological indicators of exposure. The ethereal bond may also be cut in an oxidation reaction catalyzed by the mixed function oxidase. In case of ethylene glycol, the eventual endproduct is oxalic acid. Urinary oxalic acid and alkoxyacetic acid excretion together was found to relate to the decrease of the succinate dehydrogenase activity (SDH) as an indicator of renal mitochondrial effects. The excretion of ammonia by exposed workers was doubled as compared to controls. The excretion of chloride was found to be smaller in the exposed than in controls. The excretion of calcium and glycosaminoglycans (GAG) among exposed workers were similar compared to controls.