Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Arachidonate and renal function

D B Fischer1, K F Badr

  • 1Division of Nephrology, Vanderbilt University Medical Center, Nashville, TN 37232-2372.

Current Opinion in Nephrology and Hypertension
|January 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multifocal tDCS targeting the resting state motor network increases cortical excitability beyond traditional tDCS targeting unilateral motor cortex.

NeuroImage·2017
Same author

Overexpression of 15-lipoxygenase-1 in PC-3 human prostate cancer cells increases tumorigenesis.

Carcinogenesis·2001
Same author

Ku autoantigen (DNA helicase) is required for interleukins-13/-4-induction of 15-lipoxygenase-1 gene expression in human epithelial cells.

Genes and immunity·2001
Same author

Improving longevity of prosthetic dialysis grafts in patients with disadvantaged venous outflow.

Journal of vascular surgery·2000
Same author

F(2)-isoprostanes mediate high glucose-induced TGF-beta synthesis and glomerular proteinuria in experimental type I diabetes.

Kidney international·2000
Same author

Concordant induction of 15-lipoxygenase-1 and mutant p53 expression in human prostate adenocarcinoma: correlation with Gleason staging.

Carcinogenesis·2000
Same journal

Sex differences in renal acid-base regulation.

Current opinion in nephrology and hypertension·2026
Same journal

Primary prevention of chronic kidney disease in type 2 diabetes mellitus with sodium-glucose cotransporter 2 inhibitors.

Current opinion in nephrology and hypertension·2026
Same journal

Financial and policy challenges of delivering kidney replacement therapies in resource-limited settings.

Current opinion in nephrology and hypertension·2026
Same journal

The role of kir4.1/Kir5.1 in mediating the effect of angiotensin-II on Na-Cl-cotransporter.

Current opinion in nephrology and hypertension·2026
Same journal

Role of the calcium-sensing receptor in regulating calcium transport in the thick ascending limb.

Current opinion in nephrology and hypertension·2026
Same journal

Social determinants of chronic kidney disease: from association to clinical and population action.

Current opinion in nephrology and hypertension·2026
See all related articles

Arachidonate metabolites, including thromboxane A2 and leukotriene B4, play key roles in kidney function and disease. New research highlights their inflammatory actions and potential counter-regulatory pathways in renal disorders.

Area of Science:

  • Nephrology
  • Molecular Biology
  • Immunology

Background:

  • Arachidonate-derived compounds significantly influence renal function in both health and disease.
  • Previous research has established roles for various eicosanoids in kidney physiology and pathology.

Purpose of the Study:

  • To review recent advances in understanding the roles of arachidonate metabolites in renal function.
  • To highlight new findings on the pathobiology of thromboxane A2 and leukotriene B4 in kidney disease.
  • To explore emerging evidence on the anti-inflammatory lipoxygenase pathway and other arachidonic acid metabolites.

Main Methods:

  • Review of current basic and clinical investigations.
  • Analysis of studies on thromboxane A2, leukotriene B4, and other eicosanoids.

Related Experiment Videos

  • Examination of research on cytochrome P-450 metabolites and F2-isoprostanes.

    • Main Results:

    • Thromboxane A2 is implicated in glomerular dysfunction in inflammatory disorders and diabetes.
    • Leukotriene B4 and other 5-lipoxygenase compounds contribute to glomerular injury in experimental glomerulonephritis.
    • 15-lipoxygenase products show potential as endogenous leukotriene antagonists, suggesting an anti-inflammatory role.
    • New data is available on renal cytochrome P-450 metabolites and F2-isoprostanes.

    Conclusions:

    • Recent research has expanded the understanding of arachidonate metabolites' complex roles in renal function and disease.
    • These compounds, particularly thromboxane A2 and leukotriene B4, are critical in glomerular dysfunction and inflammation.
    • Further investigation into the lipoxygenase pathway and other metabolites may reveal novel therapeutic targets for kidney diseases.