Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Genetic factors in hypertension

R P Lifton1

  • 1Eccles Institute of Human Genetics, University of Utah, Salt Lake City.

Current Opinion in Nephrology and Hypertension
|March 1, 1993
PubMed
Summary

Genetic research is revealing the causes of hypertension. Recent studies have identified key genetic mutations and mapped important gene locations, advancing our understanding of this common cardiovascular condition.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Whole-exome sequencing and immune profiling of early-stage lung adenocarcinoma with fully annotated clinical follow-up.

Annals of oncology : official journal of the European Society for Medical Oncology·2018
Same author

Phenotypic spectrum of autosomal recessive congenital ichthyosis due to PNPLA1 mutation.

The British journal of dermatology·2017
Same author

Mutation profiles in early-stage lung squamous cell carcinoma with clinical follow-up and correlation with markers of immune function.

Annals of oncology : official journal of the European Society for Medical Oncology·2017
Same author

Whole-exome sequencing and immune profiling of early-stage lung adenocarcinoma with fully annotated clinical follow-up.

Annals of oncology : official journal of the European Society for Medical Oncology·2016
Same author

Modeling non-syndromic autism and the impact of TRPC6 disruption in human neurons.

Molecular psychiatry·2014
Same author

Serial exome analysis of disease progression in premalignant gammopathies.

Leukemia·2014

Area of Science:

  • Genetics
  • Cardiovascular Disease
  • Molecular Biology

Background:

  • Hypertension is a complex disorder with significant public health implications.
  • Understanding the genetic basis of hypertension is crucial for developing effective treatments.
  • Previous research has laid the groundwork for identifying specific genetic contributors.

Purpose of the Study:

  • To explore the potential of genetic approaches in uncovering the primary abnormalities of hypertension.
  • To highlight recent advancements in the genetic study of hypertension in both animal models and human subjects.
  • To identify specific genetic factors contributing to the development of hypertension.

Main Methods:

  • Utilizing genetic mapping techniques to identify relevant loci associated with hypertension.
  • Conducting mutation analysis in animal models and human populations to pinpoint causative genetic variations.
  • Integrating data from experimental and human studies to understand pathogenic mechanisms.

Main Results:

  • Successful mapping of several quantitative trait loci (QTLs) linked to blood pressure regulation.
  • Identification of specific gene mutations contributing to the pathogenesis of hypertension in experimental animals.
  • Discovery of novel mutations associated with hypertension in human cohorts.
  • Advancement of genetic approaches from possibility to tangible reality in hypertension research.

Conclusions:

  • Genetic studies are a powerful tool for dissecting the complex etiology of hypertension.
  • Recent findings confirm the significant role of specific genetic mutations in hypertension development.
  • Continued genetic research holds promise for personalized medicine approaches to hypertension management.

Related Experiment Videos