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Kinins as vasoactive peptides
W R Fitzgibbon1, D W Ploth, H S Margolius
1Department of Medicine, Medical University of South Carolina, Charleston.
Current Opinion in Nephrology and Hypertension
|March 1, 1993
Summary
The tissue kallikrein-kinin system plays a key role in cardiovascular and renal function. Recent research clarifies its mechanisms, particularly in hypertension, using new measurement techniques and receptor studies.
Area of Science:
- Physiology
- Pharmacology
- Cardiovascular Research
Background:
- The tissue kallikrein-kinin system is crucial for regulating cardiovascular and renal functions.
- Understanding its precise role, especially in hypertension, requires advanced research methods.
Purpose of the Study:
- To review recent significant publications on the tissue kallikrein-kinin system.
- To elucidate the system's role in cardiovascular control and renal function, with a focus on hypertension.
Main Methods:
- Advances in measurement techniques for system components.
- Localization of central bradykinin receptors.
- Assessment of kinin receptor antagonists.
- Evaluation of kininase inhibitors.
Main Results:
- New data establish the critical role of the tissue kallikrein-kinin system in cardiovascular and renal regulation.
- Central bradykinin receptor localization and altered sensitivity in hypertension were identified.
- Kinin receptor antagonists and kininase inhibitors provided insights into vasorelaxation and blood pressure control.
Conclusions:
- Recent findings solidify the importance of the tissue kallikrein-kinin system in cardiovascular and renal homeostasis.
- Understanding the system's components and interactions is vital for managing hypertension.
- Further research on kinin pathways offers potential therapeutic strategies.