Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The nephritogenic immune response

R D Bloom1, R Weiss, M P Madaio

  • 1University of Pennsylvania, Philadelphia.

Current Opinion in Nephrology and Hypertension
|May 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The impact of direct-acting antiviral agents on liver and kidney transplant costs and outcomes.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2018
Same author

The American Society of Transplantation Consensus Conference on the Use of Hepatitis C Viremic Donors in Solid Organ Transplantation.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2017
Same author

Kidney Transplantation From a Donor With Sickle Cell Disease.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2016
Same author

Successful Treatment of Hepatitis C in Renal Transplant Recipients With Direct-Acting Antiviral Agents.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2015
Same author

An Assessment of HIV-Infected Patients Dying in Care for Deceased Organ Donation in a United States Urban Center.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2015
Same author

Response to: lower-dose valganciclovir for prevention of cytomegalovirus after solid organ transplant: an important tradeoff.

Transplant infectious disease : an official journal of the Transplantation Society·2015
Same journal

Sex differences in renal acid-base regulation.

Current opinion in nephrology and hypertension·2026
Same journal

Primary prevention of chronic kidney disease in type 2 diabetes mellitus with sodium-glucose cotransporter 2 inhibitors.

Current opinion in nephrology and hypertension·2026
Same journal

Financial and policy challenges of delivering kidney replacement therapies in resource-limited settings.

Current opinion in nephrology and hypertension·2026
Same journal

The role of kir4.1/Kir5.1 in mediating the effect of angiotensin-II on Na-Cl-cotransporter.

Current opinion in nephrology and hypertension·2026
Same journal

Role of the calcium-sensing receptor in regulating calcium transport in the thick ascending limb.

Current opinion in nephrology and hypertension·2026
Same journal

Social determinants of chronic kidney disease: from association to clinical and population action.

Current opinion in nephrology and hypertension·2026
See all related articles

Kidney inflammation (nephritis) arises from immune cells like antibodies and T cells interacting with kidney components. Understanding these specific interactions is key to developing targeted therapies for autoimmune kidney diseases.

Area of Science:

  • Immunology
  • Nephrology
  • Autoimmunity

Background:

  • Nephritis pathogenesis involves immune cell infiltration into the kidney.
  • Loss of self-tolerance triggers autoreactive B and T cell activation.
  • Immune deposits form via autoantibodies binding to renal or endogenous antigens.

Purpose of the Study:

  • To review recent findings on the mechanisms initiating nephritogenic immune responses.
  • To explore the roles of autoantibodies, T cells, and endogenous cells in nephritis.
  • To highlight the significance of receptor-mediated interactions in kidney autoimmunity.

Main Methods:

  • This is a review article, synthesizing existing research.
  • Focuses on analyzing studies related to immune tolerance, autoantibody formation, and T cell infiltration.

Related Experiment Videos

  • Examines the contribution of endogenous kidney cells to the inflammatory process.

    • Main Results:

    • Autoreactive lymphocytes are central to initiating nephritis.
    • Specific autoantibodies and T cells target renal antigens, forming immune deposits.
    • Endogenous kidney cells actively participate in and modulate the inflammatory response.

    Conclusions:

    • Receptor-mediated interactions are critical for immune cell localization and nephritis initiation.
    • Targeting cell surface molecules or matrix components may modulate kidney inflammation.
    • Further research into these interactions can inform novel therapeutic strategies for autoimmune kidney diseases.