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Hereditary C1q deficiency and systemic lupus erythematosus
P Bowness1, K A Davies, P J Norsworthy
1Department of Medicine, Hammersmith Hospital, London, UK.
QJM : Monthly Journal of the Association of Physicians
|August 1, 1994
Summary
Systemic lupus erythematosus (SLE) is often severe in individuals with C1q deficiency, frequently involving the central nervous system (CNS) and kidneys. This genetic condition is strongly linked to a high prevalence of severe SLE and characteristic autoantibodies.
Area of Science:
- Immunology
- Rheumatology
- Genetics
Background:
- Complement component 1q (C1q) deficiency is a rare genetic disorder.
- C1q deficiency is strongly associated with autoimmune diseases, particularly systemic lupus erythematosus (SLE).