Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Tumor spectrum analysis in p53-mutant mice

T Jacks1, L Remington, B O Williams

  • 1Center for Cancer Research, Massachusetts Institute of Technology, Cambridge 02139.

Current Biology : CB
|January 1, 1994
PubMed
Summary

The p53 tumor suppressor gene is crucial for preventing cancer. Disrupting p53 in mice leads to increased cancer predisposition and altered tumor development, highlighting its role in tumorigenesis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mice deleted for cell division cycle 73 gene develop parathyroid and uterine tumours: model for the hyperparathyroidism-jaw tumour syndrome.

Oncogene·2017
Same author

Protocol for the Electroencephalography Guidance of Anesthesia to Alleviate Geriatric Syndromes (ENGAGES) study: a pragmatic, randomised clinical trial.

BMJ open·2016
Same author

Myeloid-specific TGF-β signaling in bone promotes basic-FGF and breast cancer bone metastasis.

Oncogene·2015
Same author

Thrombospondin-1 repression is mediated via distinct mechanisms in fibroblasts and epithelial cells.

Oncogene·2015
Same author

Thrombospondin-1 repression is mediated via distinct mechanisms in fibroblasts and epithelial cells.

Oncogene·2014
Same author

Wnt signaling regulates homeostasis of the periodontal ligament.

Journal of periodontal research·2014

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • The p53 tumor suppressor gene is frequently mutated in human cancers.
  • Inherited p53 mutations increase susceptibility to various tumor types.
  • p53 is a transcriptional regulator involved in DNA damage response.

Purpose of the Study:

  • To investigate the in vivo effects of p53 gene disruption.
  • To analyze the role of p53 in normal cellular function and cancer development.
  • To create and study a mouse model with a germline p53 deletion.

Main Methods:

  • Construction of a mouse strain with a germline p53 deletion mutation.
  • Analysis of p53 protein synthesis elimination.
  • Phenotypic characterization of homozygous and heterozygous mutant mice.

Related Experiment Videos

Main Results:

  • Mice with homozygous p53 deletion are viable but highly prone to malignancy.
  • Heterozygous mice also exhibit increased cancer risk with distinct tumor types.
  • Tumorigenesis in heterozygous mice often involves loss of the wild-type p53 allele.

Conclusions:

  • p53 function is not essential for normal mouse development.
  • p53 status significantly impacts tumor latency and tissue distribution.
  • This study reaffirms the critical role of p53 in tumor suppression.