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Somatic mutation. From the dark zone to the light

I C MacLennan1

  • 1Department of Immunology, University of Birmingham Medical School, UK.

Current Biology : CB
|January 1, 1994
PubMed

The affinity maturation of antibodies that occurs during immune responses to protein antigens involves site-directed hypermutation of immunoglobulin variable-region genes that is activated in germinal centres.

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