Related Experiment Video
Updated: Aug 18, 2026

Cecal Ligation Puncture Procedure
Published on: May 7, 2011
Cytokines and sepsis: pathophysiology and therapy
1Division of Geographic Medicine and Infectious Diseases, Tufts University School of Medicine, New England Medical Center Hospital, Boston, MA 02111.
Abstract:
Current therapies for sepsis are unsatisfactory, with a 50% mortality rate in patients with septic shock, regardless of etiology. Persuasive evidence shows that the majority of damage induced during sepsis is pursuant to induction and overproduction of endogenous cytokine immune mediators. Interleukin-1 and tumor necrosis factor act synergistically as strategic triggers of the cascade of cytokine-induced pathophysiology. Anticytokine therapeutic strategies, directed primarily at interleukin-1 and tumor necrosis factor modulation, have produced preliminary but exciting results in treating sepsis and other inflammatory diseases.
Related Concept Videos
The JAK-STAT Signaling Pathway
Inflammatory Response
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Determinants of Bacterial Pathogenicity and Virulence
Acute Inflammation III: Local and Systemic Effects
Bacterial Meningitis II: Pathophysiology
Inflammatory Bowel Disease III: Crohn's Disease

