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Endothelial cell interactions and integrins

¹Department of Physiology and Cell Biology (A-66), Albany Medical College, NY 12208.

New Horizons (Baltimore, Md.)

|February 1, 1993

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Leukocyte adhesion molecules mediate cell-cell adhesion and migration across the vascular barrier. This review focuses on CD11/CD18 integrins and their interactions with intercellular adhesion molecule-1 (ICAM-1) for leukocyte trafficking.

Area of Science:

Immunology
Cell Biology
Vascular Biology

Background:

Leukocyte adhesion molecules on endothelium and leukocytes are crucial for cell-cell adhesion.
These molecules regulate leukocyte trafficking across the vascular endothelial barrier.
Some adhesion molecules are constitutively present, while others are upregulated by stimuli.

Purpose of the Study:

To review the current literature on leukocyte adhesion molecules.
To specifically focus on endothelial cell interactions mediated by CD11/CD18 integrins.

Main Methods:

Literature review of studies on leukocyte adhesion molecules.
Analysis of molecular interactions between leukocytes and endothelium.
Focus on CD11/CD18 integrins and intercellular adhesion molecule (ICAM)-1.

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Main Results:

CD11/CD18 integrins bind to ICAM-1 and ICAM-2, facilitating leukocyte migration.
Selectin-mediated binding causes leukocyte rolling.
CD11/CD18 integrins stabilize and strengthen leukocyte adhesion.

Conclusions:

CD11/CD18 integrins play a critical role in leukocyte adhesion and migration.
Understanding these interactions is key to modulating leukocyte trafficking.
The review highlights the significance of integrin-ICAM interactions in vascular biology.