Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

alpha-Fetoprotein in liver disease

M G Alexander, L R Purves, R E Kirsch

    South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde
    |March 25, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    First Report of Powdery Mildew of Kenaf Caused by Leveillula taurica in South Africa.

    Plant disease·2019
    Same author

    First Report of Botrytis cinerea on Kenaf in South Africa.

    Plant disease·2019
    Same author

    First Report of Sclerotium rolfsii on Kenaf in South Africa.

    Plant disease·2019
    Same author

    Clinical trial: interferon alpha-2b continuous long-term therapy vs. repeated 24-week cycles for re-treating chronic hepatitis C.

    Alimentary pharmacology & therapeutics·2007
    Same author

    Response to: Appropriate choice of proton pump inhibitor therapy in the prevention and management of NSAID-related gastrointestinal damage.

    International journal of clinical practice·2006
    Same author

    Bronchodilating effects of salbutamol from a novel inhaler Airmax.

    Respiratory medicine·2002

    Serum alpha-fetoprotein (AFP) levels can help diagnose liver diseases. Elevated AFP is common in acute viral hepatitis and primary liver cell carcinoma, but very high levels are specific to hepatoma and acute viral hepatitis.

    Area of Science:

    • Hepatology
    • Clinical Chemistry

    Background:

    • Alpha-fetoprotein (AFP) is a protein produced during fetal development.
    • Elevated AFP levels in adults can indicate certain liver conditions, including cancer.

    Purpose of the Study:

    • To investigate the diagnostic utility of serum AFP levels in various liver diseases.
    • To differentiate between hepatoma, chronic active hepatitis, alcoholic cirrhosis, and acute viral hepatitis using AFP concentrations.

    Main Methods:

    • Radioimmunoassay was used to measure serum AFP concentrations.
    • 98 patients with diagnosed liver conditions were included in the study.

    Main Results:

    • Raised AFP levels (>30 ng/ml) were detected in 87% of acute viral hepatitis cases, 82% of primary liver cell carcinoma (hepatoma) cases, 58% of chronic active hepatitis cases, and 14% of alcoholic cirrhosis cases.

    Related Experiment Videos

  • Serum AFP levels exceeding 1,000 ng/ml were exclusively observed in patients with hepatoma and acute viral hepatitis.

    • Conclusions:

    • Serum AFP measurement is a valuable biomarker for diagnosing and differentiating liver diseases.
    • Very high AFP levels (>1,000 ng/ml) are highly suggestive of hepatoma or acute viral hepatitis.