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Related Experiment Videos

Brain areas essential or non-essential for emesis

A D Miller1, S Nonaka, J Jakus

  • 1Rockefeller University, New York, NY 10021.

Brain Research
|June 6, 1994
PubMed
Summary
This summary is machine-generated.

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Vomiting is not controlled by a single brain center. Instead, this study in cats shows that a distributed system in the medulla coordinates the complex act of emesis.

Area of Science:

  • Neuroscience
  • Physiology

Background:

  • The precise neural control of vomiting (emesis) remains incompletely understood.
  • Previous research suggests a distributed network rather than a singular vomiting center.

Purpose of the Study:

  • To identify essential and non-essential brain regions involved in coordinating vomiting.
  • To test the hypothesis of a distributed emetic control system in the medulla.

Main Methods:

  • Induced fictive vomiting in decerebrate, paralyzed cats using emetic drugs and vagal afferent stimulation.
  • Created lesions and used kainic acid injections in specific brainstem regions.
  • Examined the effects of cerebellar removal on respiratory patterns.

Main Results:

Related Experiment Videos

  • The cerebellum, rostral brain structures, and spinal cord were found to be non-essential for vomiting coordination.
  • Vomiting's respiratory components were abolished by lesions in the lateral medulla near the retrofacial nucleus.
  • Electrical stimulation of this medullary region did not induce vomiting.

    • Conclusions:

    • Emesis coordination involves a distributed system in the medulla, between the obex and retrofacial nucleus.
    • There is no single, well-defined 'vomiting center' responsible for emesis.
    • Findings support a decentralized neural network model for vomiting control.