Related Experiment Videos
Cisplatin blocks voltage-dependent calcium current in dissociated outer hair cells of guinea-pig cochlea
T Yamamoto1, S Kakehata, T Saito
1Department of physiology, Kyushu University Faculty of Medicine, Fukuoka, Japan.
Brain Research
|June 20, 1994
Abstract:
The effect of the ototoxic molecule cisplatin (cis-DDP) on the voltage-dependent Ca2+ channel in dissociated outer hair cells (OHCs) of guinea-pig cochlea was investigated using a whole-cell patch-clamp technique. Cis-DDP had antagonistic effect on the Ca2+ channel and reversibly suppressed the Ca2+ current in a concentration-dependent manner. These results suggested that one of the ototoxic mechanisms of cis-DDP is involved in the inhibition of the Ca2+ channel in OHCs.