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Neostriatal modulation of motor cortex excitability

L J Ryan1, D J Sanders

  • 1Department of Psychology, Oregon State University, Corvallis 97331-5303.

Brain Research
|July 18, 1994
PubMed
Summary

Altering neostriatal activity in rats influences motor cortex function. The basal ganglia

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Area of Science:

  • Neuroscience
  • Motor Control
  • Basal Ganglia Function

Background:

  • The basal ganglia play a crucial role in motor control.
  • Understanding the basal ganglia's influence on the motor cortex is key to deciphering motor disorders.

Purpose of the Study:

  • To investigate how the basal ganglia motor loop affects motor cortex excitability.
  • To determine the pathway through which neostriatal activity modulates cortical function.

Main Methods:

  • Pharmacologically altering neostriatal activity in ketamine-anesthetized rats.
  • Monitoring motor cortex electrical stimulation thresholds.
  • Utilizing intraneostriatal infusions of kainic acid and glutamate.
  • Recording neuronal activity of striatonigral projection neurons.

Main Results:

  • Intraneostriatal infusions of kainic acid or glutamate increased ipsilateral motor cortex thresholds.
  • The effect on cortical thresholds was dependent on thalamic projections, specifically the ventrolateral thalamic nucleus.
  • Inhibitory agents and saline vehicle did not alter cortical thresholds.

Conclusions:

  • Neostriatal modulation of cortical thresholds occurs via thalamic pathways.
  • The basal ganglia exert an inhibitory, feedforward modulation on the motor cortex and pyramidal tract.

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