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[The effect of interleukin-2, interleukin-4 and tumor necrosis factor on LAK cells activity]
1Department of Infectious Diseases, First Teaching Hospital, Beijing Medical University.
Zhonghua Yi Xue Za Zhi
|April 1, 1994
Abstract:
We studied the effect of single or combination of interleukin-2 (IL-2), interleukin-4 (IL-4) and tumor necrosis factor (TNF) on lymphokine-activated killer cells (LAK) activity which killed both of target cells HepG2 and 2 2,1,5 cells induced for seven days. It was shown that LAK activity induced by the combination of triplet of IL-2, IL-4 and TNF was higher than that induced by single or two of IL-2, IL-4 and TNF, and that enhanced LAK activity was associated with the quantity of IL-2 receptor expression and lysosomes of LAK precursors.