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beta-thromboglobulin and deep vein thrombosis

R C Smith, J Duncanson, C V Ruckley

    Thrombosis and Haemostasis
    |April 30, 1978
    PubMed
    Summary

    Plasma beta-thromboglobulin shows an association with deep vein thrombosis (DVT) and pulmonary embolism. Further research is needed to clarify its clinical utility as a diagnostic marker for venous thromboembolism.

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    European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery·2014

    Area of Science:

    • Hematology
    • Diagnostic Medicine

    Background:

    • Venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE), poses significant health risks.
    • Accurate and timely diagnosis of VTE is crucial for effective patient management.
    • Beta-thromboglobulin (betaTG) is a platelet-specific protein released during platelet activation, suggesting its potential role in thrombotic events.

    Purpose of the Study:

    • To investigate the potential of plasma beta-thromboglobulin (betaTG) as a diagnostic marker for venous thrombosis.
    • To assess betaTG levels in patients with confirmed deep vein thrombosis (DVT) or pulmonary embolism (PE).
    • To evaluate the correlation between betaTG levels and the detection of post-operative DVT using the 125I fibrinogen test (IFT).

    Main Methods:

    • Plasma betaTG levels were measured in 16 healthy volunteers, 24 patients with clinically suspected VTE, and 46 post-operative patients screened for DVT using IFT.

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  • Confirmed DVT was diagnosed via phlebogram or IFT, and PE was confirmed by lung scan.
  • betaTG levels were monitored over a subsequent week in patients with confirmed thrombotic disease.

    • Main Results:

    • The mean plasma betaTG level in normal volunteers was 33 ng/ml (range 15-117 ng/ml).
    • Of 24 patients with VTE, 22 had DVT and 2 had PE. Twelve patients presented with elevated betaTG levels (>70 ng/ml) at initial presentation.
    • A rise in betaTG was observed within 24 hours of a positive IFT for post-operative DVT, though this did not reach statistical significance (p<0.05).
    • A confirmed association between DVT and elevated betaTG levels was observed.

    Conclusions:

    • Elevated plasma beta-thromboglobulin levels are associated with deep vein thrombosis (DVT) and pulmonary embolism (PE).
    • While a correlation exists, the clinical utility of betaTG as a standalone diagnostic test for VTE requires further investigation.
    • Factors influencing betaTG levels, such as blood sampling techniques and clearance rates, need to be elucidated to fully understand its diagnostic value.