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Multiple serotonin receptor subtypes: molecular cloning and functional expression

M Teitler¹, K Herrick-Davis

¹Department of Pharmacology and Toxicology, Albany Medical College, New York 12208.

Critical Reviews in Neurobiology

|January 1, 1994

Summary

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Molecular neurobiology has revealed a vast number of serotonin (5HT) receptor genes. This review focuses on cloning strategies for these numerous 5HT receptors and their unique properties.

Area of Science:

Neuroscience
Molecular Biology
Pharmacology

Background:

The discovery of multiple serotonin (5HT) receptor genes has revolutionized the field.
Classic studies indicated multiple receptors, but the extent of diversity was unexpected.

Purpose of the Study:

To review strategies for cloning and expressing the multitude of 5HT receptors.
To highlight the unique properties and pharmacology of newly identified 5HT receptors.

Main Methods:

Cloning of 13 5HT receptor genes between 1987-1993.
Functional expression of cloned 5HT receptors.
Analysis of pharmacological data and radioligand binding studies.

Main Results:

At least 13 5HT receptor genes have been cloned and expressed.

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A fourteenth receptor is under study, suggesting further discoveries.

Evidence suggests additional 5HT receptor subtypes remain to be identified.

Conclusions:

The rapid cloning of 5HT receptors presents a challenge in organizing information.
Understanding the unique pharmacology and distribution of each receptor is crucial.
Further research is needed to identify all mammalian 5HT receptors.