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Correlation of octanol-water partition coefficients with capacity factors measured by micellar electrokinetic
Y Ishihama1, Y Oda, K Uchikawa
1Department of Physical and Analytical Chemistry, Tsukuba Research Laboratories, Eisai Co., Ltd., Ibaraki, Japan.
Chemical & Pharmaceutical Bulletin
|July 1, 1994
Abstract:
Micellar electrokinetic chromatography (MEKC) was used to measure hydrophobicity of 18 aromatic compounds. The capacity factors, which are proportional to the micelle-water distribution coefficients, were closely correlated with the octanol-water partition coefficients. The addition of Brij 35 to the charged micelle was effective in improving the correlation because the surface charges of the micelle were shielded.