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Calcitonin-producing insulinoma: clinical, immunocytochemical and cytogenetical study
M J Bugalho1, L Roque, L G Sobrinho
1Department of Endocrinology, Portuguese Cancer Institute, Lisbon, Portugal.
Clinical Endocrinology
|August 1, 1994
Abstract:
The case of a patient with a large goitre associated with hypercalcitoninaemia and fasting hypoglycaemia is reported. Pentagastrin (PG) test was negative. Repeated measurements of fasting glycaemia, insulin and C peptide established the diagnosis of insulinoma. After localization by endoscopic ultrasonography, a distal pancreatectomy was performed and a small insulinoma was recovered. Glycaemia and calcitonin (CT) became normal. The tumour cells displayed a strong immunoreactivity for insulin and CT. Cytogenetical evaluation of the tumour revealed a translocation t(1;9) (p13;p22).