Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Atherosclerosis and autoimmunity

M F Lopes-Virella¹, G Virella

¹Ralph H. Johnson Department of Veterans Affairs Medical Center, Charleston, South Carolina 29403.

Clinical Immunology and Immunopathology

|November 1, 1994

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Late adulthood mortality among African-American and white American people with Type 1 diabetes according to age at diabetes diagnosis.

Diabetic medicine : a journal of the British Diabetic Association·2018

Same author

CD36 is upregulated in mice with periodontitis and metabolic syndrome and involved in macrophage gene upregulation by palmitate.

Oral diseases·2016

Same author

Metabolic syndrome exacerbates inflammation and bone loss in periodontitis.

Journal of dental research·2014

Same author

Simvastatin inhibits LPS-induced alveolar bone loss during metabolic syndrome.

Journal of dental research·2013

Same author

Simvastatin inhibits lipopolysaccharide-induced osteoclastogenesis and reduces alveolar bone loss in experimental periodontal disease.

Journal of periodontal research·2013

Same author

Oxidized LDL immune complexes and coronary artery calcification in type 1 diabetes.

Atherosclerosis·2010

Same journal

Mechanisms of virus replication, persistence, and regulation of immune responses.

Clinical immunology and immunopathology·2020

Same journal

Cumulative subject index for volumes 86-89

Clinical immunology and immunopathology·1998

Same journal

D-penicillamine-induced pancreatic islet autoantibody production is independent of the immunogenetic background: a lesson from patients with Wilson's disease.

Clinical immunology and immunopathology·1998

Same journal

Characterization of gastric Na+/I- symporter of the rat.

Clinical immunology and immunopathology·1998

Same journal

CD8(+), radiosensitive T cells of parental origin, oppose cells capable of down-regulating cytotoxicity in murine acute lethal graft-versus-host disease.

Clinical immunology and immunopathology·1998

Same journal

Specific activity of alpha1proteinase inhibitor and alpha2macroglobulin in human serum: application to insulin-dependent diabetes mellitus.

Clinical immunology and immunopathology·1998

See all related articles

Humoral autoimmunity, involving autoantibodies and immune complexes against oxidized LDL, plays a significant role in atherosclerosis pathogenesis. These immune responses contribute to lesion development and inflammation.

Area of Science:

Immunology
Cardiovascular Research
Pathogenesis of Atherosclerosis

Background:

Immunological mechanisms have been implicated in atherosclerosis since the 1970s.
Both humoral and cellular immunity are proposed to influence atheromatous lesion development.
Autoantibodies and immune complexes show significant experimental support in atherosclerosis theories.

Purpose of the Study:

To explore the role of humoral autoimmunity in the pathogenesis of atherosclerosis.
To investigate the impact of modified lipoproteins, specifically oxidized LDL, on immune responses.
To elucidate the mechanisms by which immune complexes contribute to atheroma formation and progression.

Main Methods:

Detection of anti-oxidized LDL antibodies in circulation and atheromatous plaques.

Related Experiment Videos

Isolation of LDL-anti-LDL immune complexes (LDL-IC) from patient serum.

In vitro studies on the effects of LDL-IC on human macrophages and fibroblasts.

Main Results:

Oxidized LDL elicits humoral immune responses in animals and humans.
LDL-IC induce intracellular cholesteryl ester accumulation in macrophages and fibroblasts.
LDL-IC exposure leads to overexpression of LDL receptors and release of IL-1 and TNF-alpha.

Conclusions:

Humoral autoimmunity, particularly involving oxidized LDL and immune complexes, is strongly suggested in atherosclerosis pathogenesis.
Cytokine release (IL-1, TNF-alpha) induced by LDL-IC may promote endothelial dysfunction and smooth muscle cell proliferation.
Evidence supports a significant role for humoral autoimmune responses in the development and progression of atherosclerotic lesions.