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Related Experiment Videos

Calcitonin: discovery, development, and clinical application

D H Copp1

  • 1Department of Physiology, Faculty of Medicine, University of British Columbia, Vancouver.

Clinical and Investigative Medicine. Medecine Clinique Et Experimentale
|June 1, 1994
PubMed
Summary
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Researchers discovered calcitonin, a hormone that precisely regulates calcium levels in the body. This discovery led to new treatments for bone diseases like osteoporosis and hypercalcemia.

Area of Science:

  • Endocrinology
  • Calcium Homeostasis
  • Neuropeptide Hormones

Background:

  • Precise regulation of plasma calcium is vital for numerous physiological processes.
  • Mechanisms controlling calcium homeostasis were poorly understood in the mid-20th century.
  • Initial research focused on parathyroid hormone (PTH) and its role in hypocalcemia.

Observation:

  • A novel calcium-regulating hormone, calcitonin, was discovered.
  • Calcitonin is released in response to hypercalcemia and lowers plasma calcium.
  • Calcitonin inhibits osteolysis, counteracting PTH's effect.

Findings:

  • Calcitonin is a 32-amino acid peptide hormone produced by C cells.
  • Salmon calcitonin, isolated by the researchers, is highly potent and clinically used.

Related Experiment Videos

  • Calcitonin effectively treats Paget's disease, hypercalcemia, and osteoporosis.

    • Implications:

    • Calcitonin's discovery expanded the understanding of calcium regulation.
    • Salmon calcitonin provides potent therapeutic benefits for bone disorders and pain relief.
    • The clinical use of calcitonin generated significant revenue, particularly for osteoporosis treatment.