Related Experiment Video
Updated: Sep 27, 2026

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion
Published on: May 26, 2022
Protective role of renal nerves in the development of diabetic nephropathy
1Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson 39216-4505.
Abstract:
Although a significant correlation between the stage of nephropathy and severity of autonomic neuropathy has been demonstrated in diabetes, the mechanism of interaction between these complications is not clear. I studied the role of the renal sympathetic nerves in the development of microalbuminuria in streptozotocin-induced diabetic rats. Sprague-Dawley rats were assigned randomly to one of four groups: 1) non-diabetic sham operated group, 2) non-diabetic renal denervated group, 3) diabetic sham operated group, and 4) diabetic renal denervated group (n = 6 in each group). After recovery of renal denervation and sham operation, diabetes was induced by streptozotocin. Throughout 6 wk of the experiment, diabetes was moderately controlled with ultralente insulin (plasma glucose = 10-24mM). Urinary albumin excretion rose throughout the experiment in all groups, although the rate of increase varied between groups. Among diabetic rats, albuminuria was 3.5 fold higher in renal denervated rats than sham-operated rats in the 6th wk. Among denervated rats, diabetic rats excreted 4.9 fold higher albumin than non-diabetic rats at the end of experiment. Thus, renal denervation appears to exacerbate the progress of diabetic nephropathy in streptozotocin treated rats as judged through assessment of urinary albumin excretion. This suggests that the renal nerves may provide some protection against the progression of diabetic nephropathy. Loss of this protective role may be one mechanism by which diabetic autonomic dysfunction may aggravate the progression of diabetic nephropathy.
More Related Videos
08:15Antagonistic Effect of Jiawei Shengjiang San on a Rat Model of Diabetic Nephropathy: Related to EGFR/MAPK3/1 Signaling Pathway
Published on: May 10, 2024
10:31Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
Published on: May 2, 2025
Related Concept Videos
Blood and Nerve Supply to the Kidney
Bloody Supply to the Kidneys:
The kidneys receive their blood supply from the renal arteries, which branch off from the abdominal aorta—the main artery supplying the abdomen and lower body. The renal arteries enter the kidneys at the hilum, a notch on the medial side of each...
Nephrons
Renal Corpuscle
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous capillaries...
Diabetic Retinopathy
Diabetic Nephropathy
Diabetic Neuropathy