Effects of lindane upon reproductive function in a 3-generation study in rats

A 3-generation study, involving the feeding of lindane at dietary concentrations of 25, 50 or 100 ppm to CD strain rats, did not reveal any adverse effects upon reproductive function as compared with that of control animals. There were no major malformations, while the distribution of minor variants was not compound or dose-related. An examination at 21 days of age of 10 males and 10 females F3B animals in each group revealed a dosage related tendency for increased liver weight and enlarged hepatocytes were seen in some control and treated animals. The relevance of these latter findings was considered of doubtful importance compared with the lack of effects on the growth and reproductive performance of the preceding generations.