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Permeation of rabbit common carotid arteries with dimethyl sulfoxide
E A Bateson1, A L Busza, D E Pegg
1MRC Medical Cryobiology Group, University Department of Surgery, Cambridge, United Kingdom.
Cryobiology
|August 1, 1994
Abstract:
Proton nuclear magnetic resonance has been used to measure the kinetics of permeation of dimethyl sulfoxide in the common carotid artery of the rabbit. The process is described by the following exponential equations, where t = time in minutes: % Unexchanged at 2 degrees C = 70e-0.515t + 30e-0.104t and %Unexchanged at 22 degrees C = 70e-1.790t + 30e-0.146t. The times required for 95% equilibration were 13 min at 22 degrees C and 18 min at 2 degrees C. The corresponding times for 99% equilibration were 24 and 32 min, respectively.