[Genetic epidemiology and a matched case-control study of bilateral breast cancer in Shanghai]

A matched case-control study on breast cancer was conducted in Shanghai from September 1990 to April 1992. Forty-six cases of bilateral breast cancer and 67 unilateral cases were studied. Results indicated that family history of breast cancer, personal history of benign breast diseases, high-level education, earlier menarche, and heavier body weight were the risk factors for breast cancer with conditional logistic regression analysis. Transmission of bilateral and unilateral breast cancer maybe conformed to Medellian recessive heredity model in simple segregation analysis, and all bilateral breast cancer, asynchronous bilateral breast cancer and asynchronous premenopausal bilateral breast cancer conformed to Medellian dominant heredity, and all unilateral breast cancer conformed to Medellian co-dominant heredity in complex segregation analysis.